Does the adenosine A2A receptor stimulate the ryanodine receptor?

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Does the adenosine A2A receptor stimulate the ryanodine receptor?

A recent paper in Cardiovascular Research from HoveMadsen and colleagues [1] has investigated the role of the adenosine A2A receptor in human atrial myocytes. Elegant confocal images show that this receptor is localized at the level of the Z line in the myocyte. Their paper then proceeds to address an important physiological question; the role of this receptor. No effect was found on the amplit...

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Reply: Does the adenosine A2A receptor stimulate the ryanodine receptor?

at Penylvania State U niersity on Feruary 3, 2013 ascres.odjournals.org/ In our paper on the expression and function of the adenosine A2A receptor (A2AR) in human atrial myocytes [1], we show that agonist stimulation of this receptor induces a protein kinase A (PKA)-dependent increase in the frequency of calcium sparks and spontaneous calcium waves. We therefore investigated whether A2AR stimul...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2007

ISSN: 0008-6363

DOI: 10.1016/j.cardiores.2006.10.023